{"created":"2023-06-20T12:59:15.144916+00:00","id":974,"links":{},"metadata":{"_buckets":{"deposit":"c26fa12a-89b8-4370-8348-d5789cfb8622"},"_deposit":{"created_by":17,"id":"974","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"974"},"status":"published"},"_oai":{"id":"oai:nufs-nuas.repo.nii.ac.jp:00000974","sets":["122:126:125:99:112"]},"author_link":["677","312","678"],"control_number":"974","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"79","bibliographicPageStart":"71","bibliographic_titles":[{"bibliographic_title":"名古屋学芸大学健康・栄養研究所年報","bibliographic_titleLang":"ja"},{"bibliographic_title":"Annual Report of Institute of Health and Nutrition, Nagoya University of Arts and Sciences","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"インスリン抵抗性に関連があると考えられていたレジスチンは、近年、糖尿病患者の血管障害との関連性について注目されている。この血中レジスチン濃度に影響を及ぼすレジスチン遺伝子多型が、糖尿病合併症の発症に関与する可能性が考えられる。そこで、レジスチンSNPs（single nucleotide polymorphisms）と血清レジスチン濃度及び臨床検査項目との関連について検討した。日本人2 型糖尿病患者386名を対象として、４ 種類のレジスチンSNPs；-420 C>G、-358 G>A、+188 G>A 及び+299 G>A が血清レジスチン濃度および糖尿病合併症有病率に及ぼす影響について検討した。その結果、すべてのレジスチンSNPs において、血清レジスチン濃度は変異があるのに従って有意に増加した（p < 0.001）。さらに無変異群（どのSNPs にも全く変異が見られなかった103名）と変異群（ 4 つのうち3 つ以上が変異型ホモの28名）について比較したところ、血糖値、HbA1c、インスリン、トリグリセライド、総コレステロール及びHDL-コレステロールについては明らかな違いは認められなかった。しかし、クレアチニンクリアランスにおいて、それぞれ85±39 ml/min 及び67±27 ml/min と変異群で有意に減少した（p＝0.025）。このことから-420 C>G、+299 G>A、-358 G>A 及び+188 G>A のレジスチン遺伝子多型は血清レジスチン濃度に関与し、糖尿病性腎症の発症あるいはその進行に関係している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Resistin, which has found to increase insulin resistance, recently come to the attention because of the association with the vascular disorder in the diabetic patients. It is thought that the SNPs (single nucleotide polymorphisms) of resistin gene, which may determine serum resistin levels, contribute to the progression of diabetes complications. In this study, we investigated the association of resistin polymorphisms with serum resistin levels and prevalence of diabetic complications. We measured serum resistin concentrations and clinical laboratory, and examined the association with the frequencies of SNPs; -420 C>G, -358 G>A, +188 G>A, and +299 G>A of resistin gene in 386 Japanese type 2 diabetic patients. In all resistin polymorphisms, serum resistin level significantly increased according to the presence of mutations (p<0.001). In the comparison with wild (wild type in all polymorphisms) and mutation group (three or four variants among four polymorphisms), blood glucose level, HbA1c, insulin, triglycerides, total cholesterol and HDL-cholesterol did not have the significant difference. On the other hand, the creatinine clearance significantly decreased in mutation group (p=0.025). Thus, SNPs of -420 C>G, -358 G>A, +188 G>A, and +299 G>A in the resistin gene are associated with serum resistin level. Furthermore, results of this study suggest that this polymorphisms play a part in the onset or the development of diabetic nephropathy.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"名古屋学芸大学健康・栄養研究所","subitem_publisher_language":"ja"}]},"item_10002_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"名古屋学芸大学健康・栄養研究所"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nuas.ac.jp/IHN/index.html","subitem_relation_type_select":"URI"}}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18821820","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Tsukahara, Takayoshi","creatorNameLang":"en"},{"creatorName":"塚原, 丘美","creatorNameLang":"ja"},{"creatorName":"ツカハラ, タカヨシ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Watarai, Atsuko","creatorNameLang":"en"},{"creatorName":"渡会, 敦子","creatorNameLang":"ja"},{"creatorName":"ワタライ, アツコ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Nakashima, Eitaro","creatorNameLang":"en"},{"creatorName":"中島, 英太郎","creatorNameLang":"ja"},{"creatorName":"ナカシマ, エイタロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-06-20"}],"displaytype":"detail","filename":"ihn02_07.pdf","filesize":[{"value":"700.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://nufs-nuas.repo.nii.ac.jp/record/974/files/ihn02_07.pdf"},"version_id":"3feba5a2-de6b-4879-afbd-912b9dd5641c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"レジスチン","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病性腎症","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resistin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetic nephropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"日本人2型糖尿病患者におけるレジスチン遺伝子多型と血清レジスチン濃度及び糖尿病合併症との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"日本人2型糖尿病患者におけるレジスチン遺伝子多型と血清レジスチン濃度及び糖尿病合併症との関連","subitem_title_language":"ja"},{"subitem_title":"Association of resistin polymorphisms with serum resistin levels and diabetic complications in Japanese type 2 diabetic patients","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"17","path":["112"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-20"},"publish_date":"2016-06-20","publish_status":"0","recid":"974","relation_version_is_last":true,"title":["日本人2型糖尿病患者におけるレジスチン遺伝子多型と血清レジスチン濃度及び糖尿病合併症との関連"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-10-16T07:53:49.793092+00:00"}